| http://purl.uniprot.org/citations/15579904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15579904 | http://www.w3.org/2000/01/rdf-schema#comment | "Keratinocyte integrins alpha6beta4 and alpha3beta1 bind laminin-5, a component of basement membranes. We previously demonstrated that in keratinocytes, haptotactic migration on laminin-5 was stimulated by anti-beta1 integrin-activating antibody TS2/16, whereas antibodies to alpha6 and beta4, respectively, blocked TS2/16-induced, alpha3beta1-dependent migration. Moreover, alpha6beta4-associated haptotaxis inhibition was linked to a phosphatidylinositol 3-kinase (PI3K) pathway and required erbB2 activation. erbB2, the ligand-less member of the epidermal growth factor receptor family, was shown to form a complex with the hemidesmosomal integrin alpha6beta4. Here, we demonstrate that alpha6beta4 inhibitory effects on haptotaxis are abolished by an anti-E-cadherin antibody, which interferes with cell-cell adhesion. Furthermore, antibodies to alpha6 and beta4 stimulated adhesion to an E-cadherin-Fc recombinant protein. In addition, anti-alpha6/beta4 antibodies increased colony size in plated cells, stimulated cell-cell aggregation, and up-regulated E-cadherin localization to cell-cell contacts. These effects were abolished when erbB2 or PI3K were blocked. These results indicate that stimulation of alpha6beta4 increases E-cadherin-mediated cell-cell adhesion and that this mechanism depends on erbB2 activation. The molecule that links alpha6beta4 with E-cadherin may be the small GTPase cdc42, an effector of PI3K, because dominant-negative cdc42 abolished the inhibitory effect of anti-alpha6/beta4 antibodies and increased basal migration, whereas constitutively active cdc42 prevented the TS2/16-induced increase in haptotaxis. These findings suggest a model whereby alpha6beta4 can augment cell-cell adhesion and slow down haptotaxis over laminin-5 and point to the alpha6beta4-erbB2 heterodimer as an important signaling complex for the formation of cohesive keratinocyte layers."xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m406301200"xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/author | "O'Sullivan D."xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/author | "Yang N."xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/author | "Higgins J.M."xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/author | "Quaranta V."xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/author | "Hintermann E."xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/pages | "8004-8015"xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/title | "Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/15579904 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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