| http://purl.uniprot.org/citations/15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15581898 | http://www.w3.org/2000/01/rdf-schema#comment | "APOBEC3G is a cytidine deaminase that limits the replication of many retroviruses. This antiviral host factor is packaged into retrovirus particles, where it targets single-stranded DNA generated during reverse transcription and induces up to 2% of G-to-A mutations, which are lethal for the HIV-1 provirus. Vif protein counteracts this antiviral factor by decreasing its packaging into lentivirus particles. Here, we demonstrate that Nedd4-1, an HECT E3 ubiquitin ligase, interacts with APOBEC3G, through its WW2 and WW3 domains. As a result of this interaction, APOBEC3G undergoes post-translational modification by addition of ubiquitin moieties. Accordingly, we demonstrate that the dominant negative Nedd4-1 C/S form prevents APOBEC3G ubiquitination. Moreover, the packaging of APOBEC3G into Pr55 Gag virus-like particles and into HIV-1 virions is reduced when Nedd4-1 C/S is expressed. During HIV-1 viral production in the presence of APOBEC3G, Nedd4-1 C/S restores partially the infectivity of Deltavif HIV-1. We conclude that the ubiquitination of APOBEC3G by Nedd4-1 favors its targeting to the virus assembly site where APOBEC3G interacts with Gag and is packaged into HIV-1 particles in the absence of Vif."xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2004.10.067"xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/author | "Vigne R."xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/author | "Decroly E."xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/author | "Bessou G."xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/author | "Courcoul M."xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/author | "Douaisi M."xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/author | "Dussart S."xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/pages | "547-558"xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/title | "APOBEC3G ubiquitination by Nedd4-1 favors its packaging into HIV-1 particles."xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://purl.uniprot.org/core/volume | "345"xsd:string |
| http://purl.uniprot.org/citations/15581898 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15581898 |
| http://purl.uniprot.org/citations/15581898 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15581898 |
| http://purl.uniprot.org/uniprot/#_F2YHL6-mappedCitation-15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15581898 |
| http://purl.uniprot.org/uniprot/#_B2RSC8-mappedCitation-15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15581898 |
| http://purl.uniprot.org/uniprot/#_A0JNZ0-mappedCitation-15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15581898 |
| http://purl.uniprot.org/uniprot/#_B2LYL6-mappedCitation-15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15581898 |
| http://purl.uniprot.org/uniprot/#_P46935-mappedCitation-15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15581898 |
| http://purl.uniprot.org/uniprot/#_M4VSD8-mappedCitation-15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15581898 |
| http://purl.uniprot.org/uniprot/#_Q8BNU7-mappedCitation-15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15581898 |
| http://purl.uniprot.org/uniprot/#_Q8BU52-mappedCitation-15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15581898 |
| http://purl.uniprot.org/uniprot/#_Q05JX5-mappedCitation-15581898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15581898 |