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| http://purl.uniprot.org/citations/15582587 | http://www.w3.org/2000/01/rdf-schema#comment | "The effects of TGF-beta on expression of the platelet-derived growth factor-induced KC protein were explored in mouse mesenchymal C3H10T1/2 and pre-osteoblastic MC3T3-E1 cells to identify a potential role for TGF-beta in expression of angiogenic cytokines during osteogenic differentiation. KC is a member of the CXC chemokine family with homology to human IL-8, a potent neutrophilic chemotactic cytokine. TGF-beta treatment results in increased KC mRNA and protein secretion in C3H10T1/2 induced towards the osteoblastic lineage with all-trans-retinoic acid. This is due to up-regulated transcription rather than enhanced mRNA stability. No induction of KC expression was seen in untreated C3H10T1/2 or MC3T3-E1 upon TGF-beta stimulation. Use of the translational inhibitor cycloheximide results in mRNA "superinduction" suggesting other factors are involved that normally function to down-regulate KC expression. TGF-beta-stimulated conditioned media were a potent chemostimulant for human microvascular endothelial cells (HMEC-1). This activity could be inhibited by pre-incubation with anti-KC neutralizing antibodies."xsd:string |
| http://purl.uniprot.org/citations/15582587 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.11.035"xsd:string |
| http://purl.uniprot.org/citations/15582587 | http://purl.uniprot.org/core/author | "Bischoff D.S."xsd:string |
| http://purl.uniprot.org/citations/15582587 | http://purl.uniprot.org/core/author | "Zhu J.H."xsd:string |
| http://purl.uniprot.org/citations/15582587 | http://purl.uniprot.org/core/author | "Yamaguchi D.T."xsd:string |
| http://purl.uniprot.org/citations/15582587 | http://purl.uniprot.org/core/author | "Makhijani N.S."xsd:string |
| http://purl.uniprot.org/citations/15582587 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15582587 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15582587 | http://purl.uniprot.org/core/pages | "364-370"xsd:string |
| http://purl.uniprot.org/citations/15582587 | http://purl.uniprot.org/core/title | "KC chemokine expression by TGF-beta in C3H10T1/2 cells induced towards osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/15582587 | http://purl.uniprot.org/core/volume | "326"xsd:string |
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