| http://purl.uniprot.org/citations/15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15583837 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphoinositol (PhoIns)-specific phospholipase C enzymes (PLCs) are central to the inositol lipid signaling pathways and contribute to intracellular Ca2+ release and protein kinase C activation. Five distinct classes of PhoIns-specific PLCs are known to exist in mammals, which are activated by membrane receptor-mediated events. Here we have identified a sixth class of PhoIns-specific PLC with a novel domain structure, which we have termed PLC-eta. Two putative PLC-eta enzymes were identified in humans and in mice. Sequence analysis revealed that residues implicated in substrate binding and catalysis from other PhoIns-specific PLCs are conserved in the novel enzymes. PLC-eta enzymes are most closely related to the PLC-delta class and share a close evolutionary relationship with other PLC isozymes. EST analysis and RT-PCR data suggest that PLC-eta enzymes are expressed in several cell types and, by analogy with other mammalian PhoIns-specific PLCs, are likely to be involved in signal transduction pathways."xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/author | "Mukherjee J."xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/author | "Stewart A.J."xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/author | "Farquharson C."xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/author | "Lester D."xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/author | "Roberts S.J."xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/pages | "117-121"xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/title | "Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes."xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15583837 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15583837 |
| http://purl.uniprot.org/citations/15583837 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15583837 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQM2-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_A0A087WSR3-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_E0CY47-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_E0CZ95-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_A2AP18-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_F7C3A0-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_F7C512-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_A2VCM4-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_A6PWW4-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_F6UKG4-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |
| http://purl.uniprot.org/uniprot/#_H3BIW6-mappedCitation-15583837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15583837 |