| http://purl.uniprot.org/citations/15585844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15585844 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC class I-specific inhibitory receptors are expressed by a subset of memory-phenotype CD8(+) T cells. Similar to NK cells, MHC class I-specific inhibitory receptors might subserve on T cells an important negative control that participates to the prevention of autologous damage. We analyzed here human CD8(+) T cells that express the Ig-like MHC class I-specific inhibitory receptors: killer cell Ig-like receptor (KIR) and CD85j. The cell surface expression of Ig-like inhibitory MHC class I receptors was found to correlate with an advanced stage of CD8(+) T cell maturation as evidenced by the reduced proliferative potential of KIR(+) and CD85j(+) T cells associated with their high intracytoplasmic perforin content. This concomitant regulation might represent a safety mechanism to control potentially harmful cytolytic CD8(+) T cells, by raising their activation threshold. Yet, KIR(+) and CD85j(+) T cells present distinct features. KIR(+)CD8(+) T cells are poor IFN-gamma producers upon TCR engagement. In addition, KIR are barely detectable at the surface of virus-specific T cells during the course of CMV or HIV-1 infection. By contrast, CD85j(+)CD8(+) T cells produce IFN-gamma upon TCR triggering, and represent a large fraction of virus-specific T cells. Thus, the cell surface expression of Ig-like inhibitory MHC class I receptors is associated with T cell engagement into various stages of the cytolytic differentiation pathway, and the cell surface expression of CD85j or KIR witnesses to the history of qualitatively and/or quantitatively distinct T cell activation events."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.173.12.7223"xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Dechanet-Merville J."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Bonneville M."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Vivier E."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Ugolini S."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Doisne J.M."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Bossy D."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Moreau J.F."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Peyrat M.A."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Delfraissy J.F."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Venet A."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Merville P."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Pitard V."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Anfossi N."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/author | "Bonnaud O."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/pages | "7223-7229"xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/title | "Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/15585844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15585844 |
| http://purl.uniprot.org/citations/15585844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15585844 |
| http://purl.uniprot.org/uniprot/Q8NHL6#attribution-D4319F7078DA3EB38D1AE077DBA4AEC0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15585844 |