| http://purl.uniprot.org/citations/15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15589695 | http://www.w3.org/2000/01/rdf-schema#comment | "The peroxisomal beta-oxidation system consists of four steps catalysed by three enzymes: acyl-CoA oxidase, 3-hydroxyacyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (multifunctional enzyme) and thiolase. In humans, thiolase activity is encoded by one gene, whereas in rodents, three enzymes encoded by three distinct genes (i.e. thiolase A, thiolase B and SCP2/thiolase) catalyse the thiolase activity. So far, acyl-CoA oxidase- and multifunctional enzyme-deficient patients have been identified and knock-out mice for these genes have been produced. Conversely, no isolated thiolase-deficient patient has been found, and no thiolase (A or B)-deficient mice have been generated. Hence, to better understand the cause of isolated human thiolase deficiency, we disrupted the catalytic site of the mouse thiolase B by homologous recombination in order to analyse the phenotype of these thiolase B-deficient mice. Mice, made homozygous for the mutation, lack expression of thiolase B mRNA and are viable, fertile and healthy at birth. They exhibit no detectable phenotype defects and no compensation, rather a slight decrease in other peroxisomal thiolase (thiolase A and SCPx) mRNAs, was found."xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biochi.2004.09.028"xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://purl.uniprot.org/core/author | "Latruffe N."xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://purl.uniprot.org/core/author | "Chevillard G."xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://purl.uniprot.org/core/author | "Nicolas-Frances V."xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://purl.uniprot.org/core/author | "Clemencet M.C."xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15589695 | http://purl.uniprot.org/core/name | "Biochimie"xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://purl.uniprot.org/core/pages | "849-856"xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://purl.uniprot.org/core/title | "Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism."xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/15589695 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15589695 |
| http://purl.uniprot.org/citations/15589695 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15589695 |
| http://purl.uniprot.org/uniprot/#_H3BJC1-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |
| http://purl.uniprot.org/uniprot/#_H3BJG8-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |
| http://purl.uniprot.org/uniprot/#_H3BJZ9-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |
| http://purl.uniprot.org/uniprot/#_H3BKA1-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |
| http://purl.uniprot.org/uniprot/#_H3BKL5-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |
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| http://purl.uniprot.org/uniprot/#_Q8BLD7-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |
| http://purl.uniprot.org/uniprot/#_Q3TUU3-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |
| http://purl.uniprot.org/uniprot/#_Q3UPU8-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |
| http://purl.uniprot.org/uniprot/#_Q921H8-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |
| http://purl.uniprot.org/uniprot/#_Q8R343-mappedCitation-15589695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15589695 |