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| http://purl.uniprot.org/citations/15589840 | http://www.w3.org/2000/01/rdf-schema#comment | "Human Tid-1 (hTid-1) is a DnaJ chaperone protein with homology to the Drosophila tumor suppressor Tid56. We report the first case of a tumor-associated mutation at the human TID1 locus, which was identified in the SF767 glioma cell line giving rise to aberrantly high levels of a hTid-1(L) mutant variant. In this study, we set out to determine whether this change in hTid-1 status influences the response of glioma cells to adenoviral (Ad)-mediated delivery of the two major isoforms of TID1, hTid-1(L) and hTid-1(S). Ad-hTid-1(S) induced apoptosis in hTid-1 mutant SF767 cells, while causing growth arrest in wild-type hTid-1-expressing U373 and U87 cells. By contrast, Ad-hTid-1(L) infection had no apparent effect on glioma cell growth. The apoptosis induced by hTid-1(S) was accompanied by mitochondrial cytochrome C release and caspase activation and blocked by stable overexpression of Bcl-X(L). Our findings suggest that the status of hTid-1 in gliomas may contribute to their susceptibility to cell death triggers."xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2004.11.034"xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/author | "Tang D."xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/author | "Rozakis-Adcock M."xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/author | "Trentin G.A."xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/author | "Wu D.C."xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/pages | "323-330"xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/title | "Identification of a hTid-1 mutation which sensitizes gliomas to apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15589840 | http://purl.uniprot.org/core/volume | "578"xsd:string |
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