| http://purl.uniprot.org/citations/15590937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15590937 | http://www.w3.org/2000/01/rdf-schema#comment | "In the dentate gyrus (DG) of the adult mouse hippocampus, a substantial number of new cells are generated daily, but only a subset of these survive and differentiate into mature neurons, whereas the majority undergo programmed cell death (PCD). However, neither the intracellular machinery required for adult stem cell-derived neuronal death nor the biological implications of the significant loss of these newly generated cells have been examined. Several markers for apoptosis failed to reveal cell death in Bax-deficient mice, and this, together with a progressive increase in neuron number in the DG of the Bax knock-out, indicates that Bax is critical for the PCD of adult-generated hippocampal neurons. Whereas the proliferation of neural progenitor cells was not altered in the Bax-knock-out, there was an accumulation of doublecortin, calretinin+, and neuronal-specific nuclear protein+ postmitotic neurons, suggesting that Bax-mediated PCD of adult-generated neurons takes place during an early phase of differentiation. The absence of PCD in the adult also influenced the migration and maturation of adult-generated DG neurons. These results suggest that PCD in the adult brain plays a significant role in the regulation of multiple aspects of adult neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1436-04.2004"xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/author | "Oppenheim R.W."xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/author | "Park O.H."xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/author | "Winseck A."xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/author | "Vinsant S."xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/pages | "11205-11213"xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/title | "Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax."xsd:string |
| http://purl.uniprot.org/citations/15590937 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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