| http://purl.uniprot.org/citations/15591776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15591776 | http://www.w3.org/2000/01/rdf-schema#comment | "We compared the acute effect of insulin on the human colonic intestinal epithelial cell line CaCo-2 and the transformed human hepatic cell line HepG2. Over 24 h, 100 nM and 10 microM insulin significantly inhibited the secretion of apolipoprotein (apo) B-100 from HepG2 cells to 63 and 49% of control, respectively. Insulin had no effect on the secretion of apoB-48 from CaCo-2 cells. There was no effect of insulin on the cholesterol ester or free cholesterol concentrations in HepG2 or CaCo-2 cells. HepG2 and CaCo-2 cells bound insulin with high affinity, leading to similar stimulation of insulin receptor protein tyrosine kinase activation. Protein kinase C or mitogen-activated protein kinase activity in the presence or absence of insulin was not correlated with apoB-48 production in CaCo-2 cells. Therefore, insulin acutely decreases the secretion of apoB-100 in hepatic HepG2 cells, but does not acutely modulate the production or secretion of apoB-48 from CaCo-2 intestinal cells."xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf02254364"xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/author | "Pal S."xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/author | "Thomson A.M."xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/author | "Mamo J.C."xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/author | "Allister E.M."xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/author | "Helmerhorst E."xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/name | "J Biomed Sci"xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/pages | "789-798"xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/title | "Insulin decreases the secretion of apoB-100 from hepatic HepG2 cells but does not decrease the secretion of apoB-48 from intestinal CaCo-2 cells."xsd:string |
| http://purl.uniprot.org/citations/15591776 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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