| http://purl.uniprot.org/citations/15596808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15596808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15596808 | http://www.w3.org/2000/01/rdf-schema#comment | "The human immunodeficiency virus (HIV) transactivator protein, Tat, stimulates transcription from the viral long terminal repeats via an arginine-rich transactivating domain. Since arginines are often known to be methylated, we investigated whether HIV type 1 (HIV-1) Tat was a substrate for known protein arginine methyltransferases (PRMTs). Here we identify Tat as a substrate for the arginine methyltransferase, PRMT6. Tat is specifically associated with and methylated by PRMT6 within cells. Overexpression of wild-type PRMT6, but not a methylase-inactive PRMT6 mutant, decreased Tat transactivation of an HIV-1 long terminal repeat luciferase reporter plasmid in a dose-dependent manner. Knocking down PRMT6 consistently increased HIV-1 production in HEK293T cells and also led to increased viral infectiousness as shown in multinuclear activation of a galactosidase indicator assays. Our study demonstrates that arginine methylation of Tat negatively regulates its transactivation activity and that PRMT6 acts as a restriction factor for HIV replication."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.1.124-131.2005"xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.1.124-131.2005"xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Bedford M.T."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Bedford M.T."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Liang C."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Liang C."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Richard S."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Richard S."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Russell R.S."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Russell R.S."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Wainberg M.A."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Wainberg M.A."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Boulanger M.C."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/author | "Boulanger M.C."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/pages | "124-131"xsd:string |
| http://purl.uniprot.org/citations/15596808 | http://purl.uniprot.org/core/pages | "124-131"xsd:string |