| http://purl.uniprot.org/citations/15598821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15598821 | http://www.w3.org/2000/01/rdf-schema#comment | "The HO gene in Saccharomyces cerevisiae is regulated by a large and complex promoter that is similar to promoters in higher order eukaryotes. Within this promoter are 10 potential binding sites for the a1-alpha2 heterodimer, which represses HO and other haploid-specific genes in diploid yeast cells. We have determined that a1-alpha2 binds to these sites with differing affinity, and that while certain strong-affinity sites are crucial for repression of HO, some of the weak-affinity sites are dispensable. However, these weak-affinity a1-alpha2-binding sites are strongly conserved in related yeast species and have a role in maintaining repression upon the loss of strong-affinity sites. We found that these weak sites are sufficient for a1-alpha2 to partially repress HO and recruit the Tup1-Cyc8 (Tup1-Ssn6) co-repressor complex to the HO promoter. We demonstrate that the Swi5 activator protein is not bound to URS1 in diploid cells, suggesting that recruitment of the Tup1-Cyc8 complex by a1-alpha2 prevents DNA binding by activator proteins resulting in repression of HO."xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkh985"xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/author | "Vershon A.K."xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/author | "Mathias J.R."xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/author | "Hanlon S.E."xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/author | "O'Flanagan R.A."xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/author | "Sengupta A.M."xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/pages | "6469-6478"xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/title | "Repression of the yeast HO gene by the MATalpha2 and MATa1 homeodomain proteins."xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/15598821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15598821 |
| http://purl.uniprot.org/citations/15598821 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15598821 |
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