| http://purl.uniprot.org/citations/15598970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15598970 | http://www.w3.org/2000/01/rdf-schema#comment | "To study the functional role of individual alpha1-adrenergic (AR) subtypes in blood pressure (BP) regulation, we used mice lacking the alpha1B-AR and/or alpha1D-AR with the same genetic background and further studied their hemodynamic and vasoconstrictive responses. Both the alpha1D-AR knockout and alpha1B-/alpha1D-AR double knockout mice, but not the alpha1B-AR knockout mice, had significantly (p < 0.05) lower levels of basal systolic and mean arterial BP than wild-type mice in nonanesthetized condition, and they showed no significant change in heart rate or in cardiac function, as assessed by echocardiogram. All mutants showed a significantly (p < 0.05) reduced catecholamine-induced pressor and vasoconstriction responses. It is noteworthy that the infusion of norepinephrine did not elicit any pressor response at all in alpha1B-/alpha1D-AR double knockout mice. In an attempt to further examine alpha1-AR subtype, which is involved in the genesis or maintenance of hypertension, BP after salt loading was monitored by tail-cuff readings and confirmed at the endpoint by direct intra-arterial recording. After salt loading, alpha1B-AR knockout mice developed a comparable level of hypertension to wild-type mice, whereas mice lacking alpha1D-AR had significantly (p < 0.05) attenuated BP and lower levels of circulating catecholamines. Our data indicated that alpha1B- and alpha1D-AR subtypes participate cooperatively in BP regulation; however, the deletion of the functional alpha1D-AR, not alpha1B-AR, leads to an antihypertensive effect. The study shows differential contributions of alpha1B- and alpha1D-ARs in BP regulation."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.org/dc/terms/identifier | "doi:10.1124/mol.104.007500"xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Fukuda S."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Kitamura T."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Cotecchia S."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Tsujimoto G."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Tanoue A."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Takeo S."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Hosoda C."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Koshimizu T.A."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Shinoura H."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Nasa Y."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Oshikawa S."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Oikawa R."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/author | "Tomabechi T."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/name | "Mol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/pages | "912-922"xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/title | "Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation."xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/15598970 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15598970 |
| http://purl.uniprot.org/citations/15598970 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15598970 |
| http://purl.uniprot.org/uniprot/#_A2ANQ2-mappedCitation-15598970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15598970 |
| http://purl.uniprot.org/uniprot/#_B1AU41-mappedCitation-15598970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15598970 |