| http://purl.uniprot.org/citations/15603741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15603741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15603741 | http://www.w3.org/2000/01/rdf-schema#comment | "Palmitoylation is a lipid modification that plays a critical role in protein trafficking and function throughout the nervous system. Palmitoylation of PSD-95 is essential for its regulation of AMPA receptors and synaptic plasticity. The enzymes that mediate palmitoyl acyl transfer to PSD-95 have not yet been identified; however, proteins containing a DHHC cysteine-rich domain mediate palmitoyl acyl transferase activity in yeast. Here, we isolated 23 mammalian DHHC proteins and found that a subset specifically palmitoylated PSD-95 in vitro and in vivo. These PSD-95 palmitoyl transferases (P-PATs) showed substrate specificity, as they did not all enhance palmitoylation of Lck, SNAP-25b, Galpha(s), or H-Ras in cultured cells. Inhibition of P-PAT activity in neurons reduced palmitoylation and synaptic clustering of PSD-95 and diminished AMPA receptor-mediated neurotransmission. This study suggests that P-PATs regulate synaptic function through PSD-95 palmitoylation."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2004.12.005"xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2004.12.005"xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Fukata M."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Fukata M."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Fukata Y."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Fukata Y."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Bredt D.S."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Bredt D.S."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Adesnik H."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Adesnik H."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Nicoll R.A."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/author | "Nicoll R.A."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/pages | "987-996"xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/pages | "987-996"xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/title | "Identification of PSD-95 palmitoylating enzymes."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/title | "Identification of PSD-95 palmitoylating enzymes."xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/15603741 | http://purl.uniprot.org/core/volume | "44"xsd:string |