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http://purl.uniprot.org/citations/15604417http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15604417http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The proatherogenic effect of IL-18 is shown to be dependent on IFN-gamma production. It is believed that activated T cells play a proatherogenic role through secretion of IFN-gamma. However, recent studies in vitro have shown that macrophages, NK cells, and even vascular smooth muscle cells may also secrete IFN-gamma after stimulation by cytokines like IL-18. We therefore investigated whether cells other than activated T cells can play a proatherogenic role via IFN-gamma secretion under the stimulation of IL-18 in vivo.

Methods and results

SCID/apoE knockout mice were injected intraperitoneally with either IL-18 or phosphate-buffered saline 3 times per week for 7 weeks. Our results show that administration of IL-18 leads to 3-fold larger lesions and 2-fold higher circulating IFN-gamma despite the absence of T cells. In addition, increased IFN-gamma, accompanied by elevation of the scavenger receptor/chemokine CXCL16, was observed in both lesions and spleens. Furthermore, our findings revealed that macrophages, NK cells, and vascular cells were the source of IFN-gamma under the stimulation of IL-18 in the absence of T cells in vivo.

Conclusions

The current data suggest that the proatherogenic effect of IL-18 can occur in the absence of T cells and that IFN-gamma secreted by macrophages, NK cells, and vascular cells is sufficient for the disease progression."xsd:string
http://purl.uniprot.org/citations/15604417http://purl.org/dc/terms/identifier"doi:10.1161/01.atv.0000153516.02782.65"xsd:string
http://purl.uniprot.org/citations/15604417http://purl.uniprot.org/core/author"Zhou X."xsd:string
http://purl.uniprot.org/citations/15604417http://purl.uniprot.org/core/author"Sundborger A."xsd:string
http://purl.uniprot.org/citations/15604417http://purl.uniprot.org/core/author"Jawien J."xsd:string
http://purl.uniprot.org/citations/15604417http://purl.uniprot.org/core/author"Tenger C."xsd:string
http://purl.uniprot.org/citations/15604417http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15604417http://purl.uniprot.org/core/name"Arterioscler Thromb Vasc Biol"xsd:string
http://purl.uniprot.org/citations/15604417http://purl.uniprot.org/core/pages"791-796"xsd:string
http://purl.uniprot.org/citations/15604417http://purl.uniprot.org/core/title"IL-18 accelerates atherosclerosis accompanied by elevation of IFN-gamma and CXCL16 expression independently of T cells."xsd:string
http://purl.uniprot.org/citations/15604417http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/15604417http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15604417
http://purl.uniprot.org/citations/15604417http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15604417
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