| http://purl.uniprot.org/citations/15604429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15604429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15604429 | http://www.w3.org/2000/01/rdf-schema#comment | "The gammaherpesviruses are characteristically latent in lymphocytes and exploit lymphocyte proliferation to establish a large, persistent pool of latent genomes. Murine gammaherpesvirus 68 (MHV-68) allows the in vivo analysis of viral genes that contribute to this and other aspects of host colonization. In this study, the MHV-68 bcl-2 homologue, M11, was disrupted either in its BH1 homology domain or upstream of its membrane-localizing C-terminal domain. Each M11 mutant showed normal lytic replication in vitro and in vivo, but had a reduction in peak splenic latency. Lower infectious-centre titres correlated with lower in vivo B-cell activation, lower viral genome loads and reduced viral tRNA expression. This was therefore a true latency deficit, rather than a deficit in ex vivo reactivation. Stable, long-term levels of splenic latency were normal. M11 function therefore contributed specifically to viral latency amplification in infected lymphoid tissue."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.org/dc/terms/identifier | "doi:10.1099/vir.0.80480-0"xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.org/dc/terms/identifier | "doi:10.1099/vir.0.80480-0"xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "Marques S."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "Marques S."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "May J.S."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "May J.S."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "Simas J.P."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "Simas J.P."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "Stevenson P.G."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "Stevenson P.G."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "de Lima B.D."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/author | "de Lima B.D."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/pages | "31-40"xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/pages | "31-40"xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/title | "Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/title | "Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo."xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/15604429 | http://purl.uniprot.org/core/volume | "86"xsd:string |