| http://purl.uniprot.org/citations/15608651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15608651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15608651 | http://www.w3.org/2000/01/rdf-schema#comment | "The conjugation of small ubiquitin-like modifiers SUMO-1, SUMO-2 and SUMO-3 onto target proteins requires the concerted action of the specific E1-activating enzyme SAE1/SAE2, the E2-conjugating enzyme Ubc9, and an E3-like SUMO ligase. NMR chemical shift perturbation was used to identify the surface of Ubc9 that interacts with the SUMO ligase RanBP2. Unlike known ubiquitin E2-E3 interactions, RanBP2 binds to the beta-sheet of Ubc9. Mutational disruption of Ubc9-RanBP2 binding affected SUMO-2 but not SUMO-1 conjugation to Sp100 and to a newly identified RanBP2 substrate, PML. RanBP2 contains a binding site specific for SUMO-1 but not SUMO-2, indicating that a Ubc9-SUMO-1 thioester could be recruited to RanBP2 via SUMO-1 in the absence of strong binding between Ubc9 and RanBP2. Thus we show that E2-E3 interactions are not conserved across the ubiquitin-like protein superfamily and identify a RanBP2-dependent mechanism for SUMO paralog-specific conjugation."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb878"xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb878"xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Hay R.T."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Hay R.T."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Tatham M.H."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Tatham M.H."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Jaffray E."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/author | "Jaffray E."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/pages | "67-74"xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/pages | "67-74"xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/title | "Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection."xsd:string |
| http://purl.uniprot.org/citations/15608651 | http://purl.uniprot.org/core/title | "Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection."xsd:string |