| http://purl.uniprot.org/citations/15611229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15611229 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracellular Ca(2+) plays a central role in controlling lymphocyte function. Nonetheless, critical gaps remain in our understanding of the mechanisms that regulate its concentration. Although Ca(2+)-release-activated calcium (CRAC) channels are the primary Ca(2+) entry pathways in T cells, additional pathways appear to be operative in B cells. Our efforts to delineate these pathways in primary murine B cells reveal that Ca(2+)-permeant nonselective cation channels (NSCCs) operate in a cooperative fashion with CRAC. Interestingly, these non-CRAC channels are selectively activated by mechanical stress, although the mechanism overlaps with BCR-activated pathways, suggesting that they may operate in concert to produce functionally diverse Ca(2+) signals. NSCCs also regulate the membrane potential, which activates integrin-dependent binding of B cells to extracellular matrix elements involved in their trafficking and localization within secondary lymphoid organs. Thus, CRAC and distinct Ca(2+) permeant NSCCs are differentially activated by the BCR and mechanical stimuli and regulate distinct aspects of B cell physiology."xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.1.68"xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/author | "King L."xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/author | "Wen Z."xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/author | "Monroe J."xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/author | "Freedman B.D."xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/author | "Liu Q.H."xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/author | "Hondowicz B."xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/pages | "68-79"xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/title | "Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli."xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15611229 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15611229 |
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