| http://purl.uniprot.org/citations/15613432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15613432 | http://www.w3.org/2000/01/rdf-schema#comment | "Increases in glutamine:fructose-6-phosphate aminotransferase (GFAT) protein levels directly activate flux through the hexosamine biosynthetic pathway. This pathway has been involved as a fuel sensor in energy metabolism and development of insulin resistance. We screened the 5'-flanking region of the human GFAT gene for polymorphisms and subsequently genotyped 412 nondiabetic, metabolically characterized Caucasians for the two single-nucleotide polymorphisms (SNP) at positions -913 (G/A) and -1412 (C/G) with rare allele frequencies of 42% and 16%, respectively. The -913 G SNP was associated with significantly higher body mass index and percent body fat in men (P = 0.02 and 0.004, respectively), but not in women (P = 0.47 and 0.26, respectively). In the subgroup of individuals (n = 193) who underwent hyperinsulinemic-euglycemic clamp, an association of the -913 G SNP with insulin sensitivity independent of body mass index was not detected. Moreover, the -913 G allele in a group of 71 individuals who had undergone magnetic resonance spectroscopy was associated with higher intramyocellular lipid content (IMCL) in tibialis anterior muscle (4.21 +/-0.31 vs. 3.36 +/-0.35; P = 0.04) independent of percent body fat and maximal aerobic power. The -1412 SNP had no effect on percent body fat, insulin sensitivity, or IMCL. In conclusion, we identified two polymorphisms in the 5'-flanking region of GFAT, of which the -913 SNP seems to alter the risk for obesity and IMCL accumulation in male subjects."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2004-0058"xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Machicao F."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Stumvoll M."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Fritsche A."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Haring H.U."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Guirguis A."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Schleicher E.D."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Thamer C."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Weigert C."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Machann J."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Schick F."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/author | "Brodbeck K."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/pages | "1639-1643"xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/title | "The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects."xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/15613432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15613432 |
| http://purl.uniprot.org/citations/15613432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15613432 |
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| http://purl.uniprot.org/uniprot/#_Q8WYR5-mappedCitation-15613432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15613432 |
| http://purl.uniprot.org/uniprot/Q06210 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15613432 |
| http://purl.uniprot.org/uniprot/Q8WYR5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15613432 |