| http://purl.uniprot.org/citations/15613740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15613740 | http://www.w3.org/2000/01/rdf-schema#comment | "Present investigations were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on oxytocin (OT) release from isolated rat hypothalamo-neurohypophysial (H-N) system as well as to determine whether the tachykinin NK-1 and/or NK-2 receptors contribute to the response of oxytocinergic neurons to melatonin. The results show, for the first time, that highly selective NK-1 receptor agonist, i.e., [Sar(9),Met(O(2))(11)]-Substance P, enhances while the NK-1 receptor antagonist (Tyr(6),D-Phe(7),D-His(9))-Substance P (6-11) - sendide - diminishes significantly OT secretion; the latter peptide was also found to antagonize the substance P-induced hormone release from isolated rat H-N system, when used at the concentration of 10(-7) M/L. Melatonin significantly inhibited basal and substance P-stimulated OT secretion. Neurokinin A and the NK-2 receptor selective agonist (beta-Ala(8))-Neurokinin A (4-10) as well as the NK-2 receptor antagonist (Tyr(5),D-Trp(6,8,9),Lys-NH(2)(10))-Neurokinin A (4-10) were essentially inactive in modifying OT release from the rat H-N system in vitro. The present data indicate a distinct role for tachykinin NK-1 (rather than NK-2) receptor in tachykinin-mediated regulation of OT secretion from the rat H-N system. Under present experimental conditions, however, a role of respective tachykinin receptors in the response of oxytocinergic neurons to melatonin has not been found."xsd:string |
| http://purl.uniprot.org/citations/15613740 | http://purl.uniprot.org/core/author | "Furykiewicz-Nykis K."xsd:string |
| http://purl.uniprot.org/citations/15613740 | http://purl.uniprot.org/core/author | "Juszczak M."xsd:string |
| http://purl.uniprot.org/citations/15613740 | http://purl.uniprot.org/core/author | "Stempniak B."xsd:string |
| http://purl.uniprot.org/citations/15613740 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15613740 | http://purl.uniprot.org/core/name | "J Physiol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/15613740 | http://purl.uniprot.org/core/pages | "739-749"xsd:string |
| http://purl.uniprot.org/citations/15613740 | http://purl.uniprot.org/core/title | "Role of tachykinin receptors and melatonin in oxitocin secretion from isolated rat hypothalmo-neurohypophysial system."xsd:string |
| http://purl.uniprot.org/citations/15613740 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/15613740 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15613740 |
| http://purl.uniprot.org/citations/15613740 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15613740 |
| http://purl.uniprot.org/uniprot/P14600#attribution-82F000CFC8A6E74BD6446AF99EC33A4F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15613740 |
| http://purl.uniprot.org/uniprot/#_P14600-mappedCitation-15613740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15613740 |
| http://purl.uniprot.org/uniprot/P14600 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15613740 |