| http://purl.uniprot.org/citations/15615787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15615787 | http://www.w3.org/2000/01/rdf-schema#comment | "Spinocerebellar ataxia type 1 (SCA1) is a dominant neurodegenerative disease caused by the expression of mutant ataxin-1 containing an expanded polyglutamine tract. Ataxin-1 is a nuclear protein that localizes to punctate inclusions similar to neuronal nuclear inclusions seen in many polyglutamine expansion disease proteins. We demonstrate that ataxin-1 localization to inclusions and inclusion dynamics within the nucleus are RNA and transcription dependent, but not dependent on the polyglutamine tract. Ataxin-1 nuclear inclusions are distinct from other described nuclear bodies but recruit the mRNA export factor, TAP/NXF1, in a manner that is enhanced by cell heat shock. By FRAP protein dynamic studies in live cells, we found that wild-type, but not mutant, ataxin-1 was capable of nuclear export. These results suggest that the normal role of ataxin-1 may be in RNA processing, perhaps nuclear RNA export. Thus, nuclear retention of mutant ataxin-1 may be an important toxic gain of function in SCA1 disease."xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.01611"xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/author | "Orr H.T."xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/author | "Graczyk J."xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/author | "Truant R."xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/author | "Vandelft M."xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/author | "Pinchev D."xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/author | "Howell J.L."xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/author | "Irwin S."xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/pages | "233-242"xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/title | "RNA association and nucleocytoplasmic shuttling by ataxin-1."xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/15615787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15615787 |
| http://purl.uniprot.org/citations/15615787 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15615787 |
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