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http://purl.uniprot.org/citations/15616244http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15616244http://www.w3.org/2000/01/rdf-schema#comment"

Objective

We studied the relationships between plasma IGF-I concentrations and insulin sensitivity in subjects with various degrees of glucose tolerance.

Research design and methods

A total of 357 nondiabetic subjects, 54 subjects with impaired glucose tolerance and 98 newly diagnosed type 2 diabetic subjects, were consecutively recruited, and anthropometric and biochemical characteristics were collected.

Results

IGF-I concentrations were negatively correlated with age, BMI, waist-to-hip ratio, triglyceride levels, and systolic and diastolic blood pressure. IGF-I concentrations were positively correlated with HDL cholesterol and homeostasis model assessment of insulin sensitivity (HOMA-S). The correlations remained significant after adjusting for sex, age, and BMI. Correlations for HOMA-S with these metabolic and anthropometric variables were of a similar degree and direction to those for IGF-I concentrations. Stepwise linear regression analysis in a model, which included well-known modulators of insulin sensitivity such as sex, age, BMI, glucose tolerance status, family history of diabetes, waist-to-hip ratio, systolic and diastolic blood pressure, HDL cholesterol, and triglyceride levels, revealed that IGF-I concentrations were independently associated with insulin sensitivity accounting for 10.8% of its variation (P < 0.0001). IGF-I concentrations were significantly lower in subjects with World Health Organization (WHO)-defined metabolic syndrome compared with subjects without metabolic syndrome (P < 0.0001). Logistic regression analysis showed that each unit increase in log-transformed IGF-I concentrations was associated with a 90.5% reduction in the risk of WHO-defined metabolic syndrome.

Conclusions

These data indicate that IGF-I has the characteristics to be a marker for the insulin resistance syndrome. This suggests that low IGF-I levels may be a useful marker for identifying subjects at risk for cardiovascular disease."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.org/dc/terms/identifier"doi:10.2337/diacare.28.1.120"xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Federici M."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Sesti G."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Cardellini M."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Lauro R."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Marini M.A."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Maio R."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Perticone F."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Sciacqua A."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Succurro E."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/author"Vatrano M."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/name"Diabetes Care"xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/pages"120-125"xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/title"Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance."xsd:string
http://purl.uniprot.org/citations/15616244http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/15616244http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15616244
http://purl.uniprot.org/citations/15616244http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15616244
http://purl.uniprot.org/uniprot/#_A0A1U9WZ84-mappedCitation-15616244http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15616244
http://purl.uniprot.org/uniprot/#_Q13429-mappedCitation-15616244http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15616244
http://purl.uniprot.org/uniprot/#_P05019-mappedCitation-15616244http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15616244
http://purl.uniprot.org/uniprot/#_Q5U743-mappedCitation-15616244http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15616244
http://purl.uniprot.org/uniprot/#_Q6LD41-mappedCitation-15616244http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15616244
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