| http://purl.uniprot.org/citations/15616578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15616578 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15616578 | http://www.w3.org/2000/01/rdf-schema#comment | "Flap endonuclease-1 (FEN1) is a key enzyme for maintaining genomic stability and replication. Proliferating cell nuclear antigen (PCNA) binds FEN1 and stimulates its endonuclease activity. The structural basis of the FEN1-PCNA interaction was revealed by the crystal structure of the complex between human FEN1 and PCNA. The main interface involves the C-terminal tail of FEN1, which forms two beta-strands connected by a short helix, the betaA-alphaA-betaB motif, participating in beta-beta and hydrophobic interactions with PCNA. These interactions are similar to those previously observed for the p21CIP1/WAF1 peptide. However, this structure involving the full-length enzyme has revealed additional interfaces that are involved in the core domain. The interactions at the interfaces maintain the enzyme in an inactive 'locked-down' orientation and might be utilized in rapid DNA-tracking by preserving the central hole of PCNA for sliding along the DNA. A hinge region present between the core domain and the C-terminal tail of FEN1 would play a role in switching the FEN1 orientation from an inactive to an active orientation."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600519"xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600519"xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Fukuda K."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Fukuda K."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Hamada K."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Hamada K."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Okada K."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Okada K."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Uchida M."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Uchida M."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Yamaguchi H."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Yamaguchi H."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Hakoshima T."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Hakoshima T."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Kitano K."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Kitano K."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Ohtsuka E."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Ohtsuka E."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Sakurai S."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Sakurai S."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Morioka H."xsd:string |
| http://purl.uniprot.org/citations/15616578 | http://purl.uniprot.org/core/author | "Morioka H."xsd:string |