| http://purl.uniprot.org/citations/15617035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15617035 | http://www.w3.org/2000/01/rdf-schema#comment | "The acetylation polymorphism is a common inherited variation in human drug and carcinogen metabolism. Because N-acetyltransferase (NAT2) is important for the detoxification and/or bioactivation of drugs and carcinogens, polymorphisms of this gene have important implications in therapeutics of and susceptibility to cancer. In this study, NAT2 genotype (NAT2*5A (C(481)T), NAT2*6A (G(590)A), NAT2*7A/B (G(857)A)) and NAT2*14A (G(191)A) and phenotype were determined in 125 patients with colorectal carcinoma and 82 healthy control in Mersin, a city located in the southern region of Turkey. Isolation of the subjects' DNA was performed by using a highly purified PCR template preparation kit/(Roche Diagnostics cat. no: 1 796 828) and the NAT2 polymorphism was detected using real-time PCR (Roche Diagnostics, GmbH, Mannheim, Germany). According to this study high protein intake is associated with the increased risk for the development of colon cancer (OR = 1.73; 95% CI, 1.10-3.07). Although only NAT2*14A fast type was associated with increased risk in patients with colorectal carcinoma (OR = 3.03; 95% CI, 1.56-5.86), when a high protein diet was considered, NAT2*7A/B fast genotype was also found to be associated with an increased risk (OR = 2.06, 95% CI for NAT2*7A/B, 1.10-3.86; OR = 2.65; 95% CI, 1.29-5.46 for NAT2*14A). Smoking status did not differ between the control and patient groups. Our data suggest that exposure to carcinogens through consumption of a high-protein diet may increase the risk of colorectal carcinoma only in genetically-susceptible individuals."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbf.1191"xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/author | "Ercan B."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/author | "Unlu A."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/author | "Ates C."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/author | "Atik U."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/author | "Ates N.A."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/author | "Tamer L."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/author | "Degirmenci U."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/author | "Dirlik M."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/name | "Cell Biochem Funct"xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/pages | "131-135"xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/title | "N-acetyltransferase 2 gene polymorphism in patients with colorectal carcinoma."xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15617035 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15617035 |
| http://purl.uniprot.org/citations/15617035 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15617035 |
| http://purl.uniprot.org/uniprot/#_A0A0S2A5S1-mappedCitation-15617035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15617035 |
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| http://purl.uniprot.org/uniprot/#_A0A0S2A5J2-mappedCitation-15617035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15617035 |
| http://purl.uniprot.org/uniprot/#_A4Z6U4-mappedCitation-15617035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15617035 |
| http://purl.uniprot.org/uniprot/#_A4Z6U6-mappedCitation-15617035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15617035 |
| http://purl.uniprot.org/uniprot/#_A4Z6U7-mappedCitation-15617035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15617035 |