| http://purl.uniprot.org/citations/15621568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15621568 | http://www.w3.org/2000/01/rdf-schema#comment | "Mortalin has been found to be up-regulated by 2D-protein gel analysis in isolated rodent islets exposed to cytokines. In islets from two rat strains with different sensitivity to the toxic effects of cytokines we observed a significant difference in IL-1beta mediated mortalin expression. Constitutive over-expression of rat mortalin in NIH3T3 cells reduced cellular survival in accordance with mortalin being associated to cellular senescence. Hence we consider the gene encoding for mortalin at chromosome 5q31.1 a putative candidate gene in cytokine induced beta-cell destruction. We scanned the human mortalin gene for polymorphisms and identified three novel polymorphisms. Neither the SNPs individually nor as constructed haplotypes showed disease association tested by (E)TDT in a Danish type 1 diabetes (T1DM) population. Furthermore, we tested the D5S500 microsatelite located close to 5q31.1 without finding linkage to (T1DM). In conclusion, the functional data identifying a difference in mortalin expression in IL-1beta stimulated islets between two rat strains and over-expression of mortalin in NIH3T3 cells associated with decreased viability suggests a functional role for mortalin in cytokine mediated beta cell destruction; however, the identified polymorphisms did not reveal any association in the presence of linkage disequilibrium of mortalin to T1DM in the Danish population."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.org/dc/terms/identifier | "doi:10.1080/08916930410001710037"xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/author | "Jensen A."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/author | "Vissing H."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/author | "Karlsen A.E."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/author | "Pie A."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/author | "Nerup J."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/author | "Pociot F."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/author | "Johannesen J."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/author | "Kristiansen O.P."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/author | "Larsen Z.M."xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/name | "Autoimmunity"xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/pages | "423-430"xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/title | "Is mortalin a candidate gene for T1DM ?"xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/15621568 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15621568 |
| http://purl.uniprot.org/citations/15621568 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15621568 |
| http://purl.uniprot.org/uniprot/P48721#attribution-B47203269AEFCE47BEA063F676BD9090 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15621568 |
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| http://purl.uniprot.org/uniprot/#_P48721-mappedCitation-15621568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15621568 |
| http://purl.uniprot.org/uniprot/P48721 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15621568 |
| http://purl.uniprot.org/uniprot/F1M953 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15621568 |