| http://purl.uniprot.org/citations/15629423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15629423 | http://www.w3.org/2000/01/rdf-schema#comment | "APH-1 is a polytopic membrane protein that functions as a component of presenilin-gamma-secretase complexes. Two homologous genes of APH-1 exist in humans, APH-1a and APH-1b, and alternative splicing of the former generates two isoforms, APH-1aS and APH-1aL. We performed semi-quantitative reverse transcription-PCR analysis to investigate mRNA expression of these three APH-1 forms in human cell lines and tissues. We found that both APH-1a and APH-1b were expressed in almost all tissues, and that APH-1aS was 1.5-3 times more abundantly expressed than APH-1aL. We examined the effect of small interfering RNA-mediated knock down of APH-1a or APH-1b on APH-1 mRNA expression and presenilin complex protein expression. We found that knock down of APH-1a, but not APH-1b, resulted in impaired maturation of nicastrin and reduced expression of presenilin 1, presenilin 2, and PEN-2 proteins. These findings indicate that APH-1a plays an essential role in the formation of presenilin-gamma-secretase complexes."xsd:string |
| http://purl.uniprot.org/citations/15629423 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.11.130"xsd:string |
| http://purl.uniprot.org/citations/15629423 | http://purl.uniprot.org/core/author | "Saito S."xsd:string |
| http://purl.uniprot.org/citations/15629423 | http://purl.uniprot.org/core/author | "Araki W."xsd:string |
| http://purl.uniprot.org/citations/15629423 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15629423 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15629423 | http://purl.uniprot.org/core/pages | "18-22"xsd:string |
| http://purl.uniprot.org/citations/15629423 | http://purl.uniprot.org/core/title | "Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes."xsd:string |
| http://purl.uniprot.org/citations/15629423 | http://purl.uniprot.org/core/volume | "327"xsd:string |
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