| http://purl.uniprot.org/citations/15631996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15631996 | http://www.w3.org/2000/01/rdf-schema#comment | "Left ventricular (LV) hypertrophy is a natural response of the heart to increased pressure loading, but accompanying fibrosis and dilatation may result in irreversible life-threatening heart failure. Matrix metalloproteinases (MMPs) have been invoked in various cardiac diseases, however, direct genetic evidence for a role of the plasminogen activator (PA) and MMP systems in pressure overload-induced LV hypertrophy and in heart failure is lacking. Therefore, the consequences of transverse aortic banding (TAB) were analyzed in mice lacking tissue-type PA (t-PA(-/-)), urokinase-type PA (u-PA(-/-)), or gelatinase-B (MMP-9(-/-)), and in wild-type (WT) mice after adenoviral gene transfer of the PA-inhibitor PAI-1 or the MMP-inhibitor TIMP-1. TAB elevated LV pressure comparably in all genotypes. In WT and t-PA(-/-) mice, cardiomyocyte hypertrophy was associated with myocardial fibrosis, LV dilatation and dysfunction, and pump failure after 7 weeks. In contrast, in u-PA(-/-) mice or in WT mice after PAI-1- and TIMP-1-gene transfer, cardiomyocyte hypertrophy was moderate and only minimally associated with cardiac fibrosis and LV dilatation, resulting in better preservation of pump function. Deficiency of MMP-9 had an intermediate effect. These findings suggest that the use of u-PA- or MMP-inhibitors might preserve cardiac pump function in LV pressure overloading."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)62228-6"xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/author | "Baker A."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/author | "Collen D."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/author | "Carmeliet P."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/author | "Lupu F."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/author | "Moons L."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/author | "Heymans S."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/author | "Herbert J.M."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/author | "Terclavers S."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/author | "Vanwetswinkel B."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/pages | "15-25"xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/title | "Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice."xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/15631996 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15631996 |
| http://purl.uniprot.org/citations/15631996 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15631996 |
| http://purl.uniprot.org/uniprot/#_P11214-mappedCitation-15631996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15631996 |
| http://purl.uniprot.org/uniprot/#_Q0VBA8-mappedCitation-15631996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15631996 |
| http://purl.uniprot.org/uniprot/#_A2A5K8-mappedCitation-15631996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15631996 |
| http://purl.uniprot.org/uniprot/#_A0A286YE40-mappedCitation-15631996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15631996 |
| http://purl.uniprot.org/uniprot/#_P41245-mappedCitation-15631996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15631996 |
| http://purl.uniprot.org/uniprot/#_Q2M4J5-mappedCitation-15631996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15631996 |