| http://purl.uniprot.org/citations/15632007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15632007 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanism of nasal-associated lymphoid tissue (NALT) development is incompletely understood with regard to the roles of cytokines, chemokines, and vascular addressins. Development of the wild-type NALT continued in the immediate postnatal period with gradual increases in cellularity, compartmentalization into T- and B-cell zones, and expression of lymphotoxin (LT)-alpha, LT-beta, and lymphoid chemokines (CCL21, CCL19, CXCL13). High endothelial venules (HEVs) developed that expressed GlyCAM-1, HEC-6ST [an enzyme crucial for expression of luminal peripheral node addressin (PNAd)], and PNAd itself. LT-beta(-/-) and LT-alpha(-/-) NALTs had fewer cells than those of wild-type mice, reduced (LT-beta(-/-)) or absent (LT-alpha(-/-)) lymphoid chemokines, and no T- and B-cell compartmentalization. LT-beta(-/-) HEVs expressed only abluminal PNAd and no HEC-6ST or GlyCAM-1. LT-alpha(-/-) HEVs had no PNAd, HEC-6ST, or GlyCAM-1. Because intranasal immunization gives rise to vaginal IgA, immunization of LT-beta(-/-) mice, which retain cervical lymph nodes, might generate such a response. Intranasal immunization with ovalbumin and cholera toxin revealed lower cytokine levels in the LT-alpha(-/-) and LT-beta(-/-) NALTs, and undetectable vaginal IgA. In contrast, splenic cytokines and serum IgG titers, although reduced, were detectable. These data indicate that LT-alpha(3) and LT-alpha(1)beta(2) cooperatively contribute to NALT development and function through regulation of lymphoid chemokines and adhesion molecules; they are the first to implicate LT-alpha(1)beta(2) in GlyCAM-1 regulation in NALT HEV development."xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)62239-0"xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/author | "Chan K."xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/author | "Ruddle N.H."xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/author | "Hill M."xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/author | "Ying X."xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/author | "Shenoy P."xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/pages | "135-146"xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/title | "Lymphotoxin plays a crucial role in the development and function of nasal-associated lymphoid tissue through regulation of chemokines and peripheral node addressin."xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/15632007 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15632007 |
| http://purl.uniprot.org/citations/15632007 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15632007 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JAA2-mappedCitation-15632007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15632007 |
| http://purl.uniprot.org/uniprot/#_A4FUI4-mappedCitation-15632007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15632007 |
| http://purl.uniprot.org/uniprot/#_G3V002-mappedCitation-15632007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15632007 |
| http://purl.uniprot.org/uniprot/#_P41155-mappedCitation-15632007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15632007 |
| http://purl.uniprot.org/uniprot/#_P09225-mappedCitation-15632007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15632007 |
| http://purl.uniprot.org/uniprot/#_Q542S2-mappedCitation-15632007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15632007 |
| http://purl.uniprot.org/uniprot/#_Q3U0Q5-mappedCitation-15632007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15632007 |
| http://purl.uniprot.org/uniprot/A0A0U5JAA2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15632007 |
| http://purl.uniprot.org/uniprot/P41155 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15632007 |
| http://purl.uniprot.org/uniprot/Q3U0Q5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15632007 |