| http://purl.uniprot.org/citations/15634877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15634877 | http://www.w3.org/2000/01/rdf-schema#comment | "Engagement of the IFN-alphabeta receptor initiates multiple signaling cascades, including activation of the STAT. In this study, we demonstrate that IFN-alphabeta, although antiproliferative in wild-type CD4(+) or CD8(+) T cells, act as strong mitogens on their STAT1(-/-) counterparts. Furthermore, IFN-alphabeta exert little effect on apoptosis in wild-type cells, but are potent survival factors in the absence of STAT1. The antiapoptotic response in the absence of STAT1 is predominantly mediated by STAT3, and to a lesser extent by STAT5A/B. In contrast, the mitogenic IFN-alphabeta response gained through the absence of STAT1 is only marginally affected when STAT5A/B expression is also abrogated, but is completely dependent on STAT3 activation. These findings provide the first evidence for a function of STAT3 and STAT5A/B in the IFN-alphabeta response, and support a model in which the IFN-alphabeta receptor initiates both pro- and antiapoptotic responses through STAT1, and STAT3 and STAT5A/B, respectively."xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.2.609"xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/author | "David M."xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/author | "Tanabe Y."xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/author | "Su L."xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/author | "Arduini R.M."xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/author | "Baker D.P."xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/author | "Nishibori T."xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/pages | "609-613"xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/title | "Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15634877 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15634877 |
| http://purl.uniprot.org/citations/15634877 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15634877 |
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