| http://purl.uniprot.org/citations/15634883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15634883 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms regulating T lymphocyte migration within the extracellular matrix are not understood. We show in this study that the thrombospondin-1 binding site of calreticulin, spanning aa 19-32, is a major triggering factor for T cell motility and migration within a three-dimensional collagen type 1 matrix, and that exogenous motogenic factors such as chemokines can stimulate migration via a calreticulin-thrombospondin-1 pathway. Endogenous calreticulin binding to the N-terminal domain of endogenous thrombospondin-1 elicited a motogenic signal to the T cells through the C-terminal domain of thrombospondin-1 and its cell surface receptor integrin-associated protein (CD47). Our data further revealed that thrombospondin-1 was expressed on the cell surface with a high turnover, and that PI3K and the Janus family of tyrosine kinases were required for T cell motility mediated through calreticulin, thrombospondin-1, and CD47. These results unveil an autocrine mechanism of calreticulin-thrombospondin-1-CD47 interaction for the control of T cell motility and migration within three-dimensional extracellular matrix substrata."xsd:string |
| http://purl.uniprot.org/citations/15634883 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.2.654"xsd:string |
| http://purl.uniprot.org/citations/15634883 | http://purl.uniprot.org/core/author | "Li S.S."xsd:string |
| http://purl.uniprot.org/citations/15634883 | http://purl.uniprot.org/core/author | "Sundqvist K.G."xsd:string |
| http://purl.uniprot.org/citations/15634883 | http://purl.uniprot.org/core/author | "Forslow A."xsd:string |
| http://purl.uniprot.org/citations/15634883 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15634883 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15634883 | http://purl.uniprot.org/core/pages | "654-661"xsd:string |
| http://purl.uniprot.org/citations/15634883 | http://purl.uniprot.org/core/title | "Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction."xsd:string |
| http://purl.uniprot.org/citations/15634883 | http://purl.uniprot.org/core/volume | "174"xsd:string |
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