| http://purl.uniprot.org/citations/15637289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15637289 | http://www.w3.org/2000/01/rdf-schema#comment | "1,25-Dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) is an immune modulator that prevents experimental autoimmune diseases. Receptors for 1,25-(OH)(2)D(3) are present in pancreatic beta-cells, the target of an autoimmune assault in nonobese diabetic (NOD) mice. The aim of this study was to investigate the in vivo and in vitro effects of 1,25-(OH)(2)D(3) on beta-cell gene expression and death and correlate these findings to in vivo diabetes development in NOD mice. When female NOD mice were treated with 1,25-(OH)(2)D(3) (5 microg/kg per 2 d), there was a decrease in islet cytokine and chemokine expression, which was accompanied by less insulitis. Complementing these findings, we observed that exposure to 1,25-(OH)(2)D(3) in three cell systems INS-1(E) cell line, fluorescence-activated cell sorting purified rat beta-cells, and NOD-severe combined immunodeficient islets) suppressed IP-10 and IL-15 expression in the beta-cell itself but did not prevent cytokine-induced beta-cell death. This 1,25-(OH)(2)D(3)-induced inhibition of chemokine expression in beta-cells was associated with a decreased diabetes incidence in some treatment windows targeting early insulitis. Thus, although a short and early intervention with 1,25-(OH)(2)D(3) (3-14 wk of age) reduced diabetes incidence (35 vs. 58%, P < or = 0.05), a late intervention (from 14 wk of age, when insulitis is present) failed to prevent disease. Of note, only early and long-term treatment (3-28 wk of age) prevented disease to a major extent (more than 30% decrease in diabetes incidence). We conclude that 1,25-(OH)(2)D(3) monotherapy is most effective in preventing diabetes in NOD mice when applied early. This beneficial effect of 1,25-(OH)(2)D(3) is associated with decreased chemokine and cytokine expression by the pancreatic islets."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2004-1322"xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/author | "Mathieu C."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/author | "Bouillon R."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/author | "Eizirik D.L."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/author | "Gysemans C.A."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/author | "Cardozo A.K."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/author | "Callewaert H."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/author | "Giulietti A."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/author | "Hulshagen L."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/pages | "1956-1964"xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/title | "1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice."xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/15637289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15637289 |
| http://purl.uniprot.org/citations/15637289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15637289 |
| http://purl.uniprot.org/uniprot/P48973#attribution-9B3ECDF42CFAE35DCDC8E78D5CAD4E8F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15637289 |
| http://purl.uniprot.org/uniprot/P97604#attribution-9B3ECDF42CFAE35DCDC8E78D5CAD4E8F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15637289 |
| http://purl.uniprot.org/uniprot/#_A0A8L2Q1M6-mappedCitation-15637289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15637289 |
| http://purl.uniprot.org/uniprot/#_P48973-mappedCitation-15637289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15637289 |
| http://purl.uniprot.org/uniprot/#_P97604-mappedCitation-15637289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15637289 |
| http://purl.uniprot.org/uniprot/P97604 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15637289 |
| http://purl.uniprot.org/uniprot/P48973 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15637289 |