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http://purl.uniprot.org/citations/15640608http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15640608http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Childhood onset Graves' disease (GD) has been documented to be clinically distinct from adult onset GD, and an association with the genes encoding HLA and CTLA-4 (cytotoxic T lymphocyte antigen-4) has been reported in both Caucasian and Japanese adult GD patients. The aim of this study was to determine whether HLA-DR, -DQ and CTLA-4 are associated with childhood onset GD in Japanese individuals.

Methods

We investigated the genotype of HLA class II (DRB1, DQB1) and the A/G transition polymorphism of CTLA-4 exon 1 position 49 in 43 GD patients and in healthy controls for comparison. The CTLA-4 alleles were identified by the polymerase chain reaction (PCR) of genomic DNA and restriction fragment-length polymorphism analysis (PCR-RFLP) with Ita1.

Results

The frequency of both HLA-DRB1*0405 and DQB1*0401 was increased in the patient group (DRB1*0405: 26.7%, p < 0.001; DQB1*0401: 25.6%, p < 0.005) compared with the controls. Patients with GD had a significantly lower frequency of the AA genotype of CTLA-4 than the controls, but there was no difference in allele frequency between the G and A allele.

Conclusions

the association of HLA-DRB1 and DQB1 genotype with susceptibility to childhood onset GD differs from that in adult onset GD, whereas the association between CTLA-4 gene polymorphism and childhood onset GD is similar to that in adult onset GD in Japanese individuals, but the association is weak."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.org/dc/terms/identifier"doi:10.1159/000083137"xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Kim H.S."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Matsuoka H."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Sugihara S."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Sato H."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Sakamaki T."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Yanagawa T."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Hoshi M."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Iwama S."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Ikezaki A."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/author"Kikuoka N."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/name"Horm Res"xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/pages"55-60"xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/title"Association of HLA-DR, -DQ genotype and CTLA-4 gene polymorphism with Graves' disease in Japanese children."xsd:string
http://purl.uniprot.org/citations/15640608http://purl.uniprot.org/core/volume"63"xsd:string
http://purl.uniprot.org/citations/15640608http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15640608
http://purl.uniprot.org/citations/15640608http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15640608
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15640608http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15640608
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15640608http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15640608
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-15640608http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15640608
http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-15640608http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15640608
http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-15640608http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15640608
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