| http://purl.uniprot.org/citations/15642262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15642262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15642262 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytoskeletal protein talin plays a key role in activating integrins and in coupling them to the actin cytoskeleton. Its N-terminal globular head, which binds beta integrins, is linked to an extended rod having a C-terminal actin binding site and several vinculin binding sites (VBSs). The NMR structure of residues 755-889 of the rod (containing a VBS) is shown to be an amphipathic four-helix bundle with a left-handed topology. A talin peptide corresponding to the VBS binds the vinculin head; the X-ray crystallographic structure of this complex shows that the residues which interact with vinculin are buried in the hydrophobic core of the talin fragment. NMR shows that the interaction involves a major structural change in the talin fragment, including unfolding of one of its helices, making the VBS accessible to vinculin. Interestingly, the talin 755-889 fragment binds more than one vinculin head molecule, suggesting that the talin rod may contain additional as yet unrecognized VBSs."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.11.006"xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.11.006"xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Patel B."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Patel B."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Papagrigoriou E."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Papagrigoriou E."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Barsukov I.L."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Barsukov I.L."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Critchley D.R."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Critchley D.R."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Gingras A.R."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Gingras A.R."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Roberts G.C.K."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Roberts G.C.K."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Emsley J."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Emsley J."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Fillingham I."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/author | "Fillingham I."xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/15642262 | http://purl.uniprot.org/core/name | "Structure"xsd:string |