| http://purl.uniprot.org/citations/15642270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15642270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15642270 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factor binding proteins (IGFBPs) control the extracellular distribution, function, and activity of IGFs. Here, we report an X-ray structure of the binary complex of IGF-I and the N-terminal domain of IGFBP-4 (NBP-4, residues 3-82) and a model of the ternary complex of IGF-I, NBP-4, and the C-terminal domain (CBP-4, residues 151-232) derived from diffraction data with weak definition of the C-terminal domain. These structures show how the IGFBPs regulate IGF signaling. Key features of the structures include (1) a disulphide bond ladder that binds to IGF and partially masks the IGF residues responsible for type 1 IGF receptor (IGF-IR) binding, (2) the high-affinity IGF-I interaction site formed by residues 39-82 in a globular fold, and (3) CBP-4 interactions. Although CBP-4 does not bind individually to either IGF-I or NBP-4, in the ternary complex, CBP-4 contacts both and also blocks the IGF-IR binding region of IGF-I."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.11.009"xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.11.009"xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Huber R."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Huber R."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Holak T.A."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Holak T.A."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Engh R.A."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Engh R.A."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Lang K."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Lang K."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Wisniewska M."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Wisniewska M."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Popowicz G.M."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Popowicz G.M."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Kuenkele K.-P."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Kuenkele K.-P."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Siwanowicz I."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/author | "Siwanowicz I."xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/15642270 | http://purl.uniprot.org/core/name | "Structure"xsd:string |