| http://purl.uniprot.org/citations/15647285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15647285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15647285 | http://www.w3.org/2000/01/rdf-schema#comment | "Pulmonary eosinophilia, a hallmark pathologic feature of allergic lung disease, is regulated by interleukin-13 (IL-13) as well as the eotaxin chemokines, but the specific role of these cytokines and their cooperative interaction are only partially understood. First, we elucidated the essential role of IL-13 in the induction of the eotaxins by comparing IL-13 gene-targeted mice with wild type control mice by using an ovalbumin-induced model of allergic airway inflammation. Notably, ovalbumin-induced expressions of eotaxin-1 and eotaxin-2 mRNA in the lungs were almost completely dependent upon IL-13. Second, in order to address the specific role of eotaxin-2 in IL-13-induced pulmonary eosinophilia, we generated eotaxin-2 gene-deficient mice by homologous recombination. Notably, in contrast to observations made in eotaxin-1-deficient mice, eotaxin-2-deficient mice had normal base-line eosinophil levels in the hematopoietic tissues and gastrointestinal tract. However, following intratracheal IL-13 administration, eotaxin-2-deficient mice showed a profound reduction in airway eosinophilia compared with wild type mice. Most interestingly, the level of peribronchial lung tissue eosinophils in IL-13-treated eotaxin-2-deficient mice was indistinguishable from wild type mice. Furthermore, IL-13 lung transgenic mice genetically engineered to be deficient in eotaxin-2 had a marked reduction of luminal eosinophils. Mechanistic analysis identified IL13-induced eotaxin-2 expression by macrophages in a distinct lung compartment (luminal inflammatory cells) compared with eotaxin-1, which was expressed solely in the tissue. Taken together, these results demonstrate a cooperative mechanism between IL-13 and eotaxin-2. In particular, IL-13 mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway eosinophilia."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m406037200"xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m406037200"xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M406037200"xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Zimmermann N."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Zimmermann N."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Molkentin J.D."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Molkentin J.D."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Rothenberg M.E."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Rothenberg M.E."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Blanchard C."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Blanchard C."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Fulkerson P.C."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Fulkerson P.C."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Nikolaidis N.M."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Nikolaidis N.M."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Pope S.M."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Pope S.M."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Saito Akei H."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/author | "Saito Akei H."xsd:string |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15647285 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |