| http://purl.uniprot.org/citations/15647361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15647361 | http://www.w3.org/2000/01/rdf-schema#comment | "Immune cell cosignaling receptors are important modulators of immune cell function. For T cells, cosignaling receptors supply necessary secondary signals supporting activation or attenuation after engagement of antigen-presenting cells. The primary cosignaling receptors belong to either the Ig (CD28-like) or TNF receptor (TNFR) superfamilies. The CD28 family is comprised of coinhibitory and costimulatory receptors. The three coinhibitory receptors are cytotoxic T lymphocyte antigen 4, programmed death-1, and B and T lymphocyte attenuator (BTLA). Although cytotoxic T lymphocyte antigen 4 and programmed death-1 interact with B7-Ig family counter receptors, the ligand for BTLA is less clear. From a protein-protein interaction screen, we identified the TNFR family member herpesvirus entry mediator (HVEM) as a counter receptor for BTLA. Here we show that HVEM binds BTLA with high affinity and can form a ternary complex with its known ligands homologous to lymphotoxin, showing inducible expression, and competing with herpes simplex virus glycoprotein D for HVEM, a receptor expressed by T lymphocytes (LIGHT) or lymphotoxin alpha and BTLA. In addition, binding of HVEM to BTLA attenuates T cell activation, identifying HVEM/BTLA as a coinhibitory receptor pair. This study is a demonstration of a direct interaction between the primary T cell cosignaling receptors of the CD28 and TNFR families."xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0409071102"xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/author | "Eaton D.L."xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/author | "Ouyang W."xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/author | "Gonzalez L.C."xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/author | "Loyet K.M."xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/author | "Chauhan V."xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/author | "Calemine-Fenaux J."xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/author | "Wranik B."xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/pages | "1116-1121"xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/title | "A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator."xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/15647361 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15647361 |
| http://purl.uniprot.org/citations/15647361 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15647361 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1A0-mappedCitation-15647361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15647361 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P889-mappedCitation-15647361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15647361 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6M8-mappedCitation-15647361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15647361 |
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| http://purl.uniprot.org/uniprot/#_B4DU65-mappedCitation-15647361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15647361 |
| http://purl.uniprot.org/uniprot/#_E9QNY6-mappedCitation-15647361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15647361 |
| http://purl.uniprot.org/uniprot/#_F6Y2U8-mappedCitation-15647361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15647361 |
| http://purl.uniprot.org/uniprot/#_B4E0P6-mappedCitation-15647361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15647361 |