| http://purl.uniprot.org/citations/15647390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15647390 | http://www.w3.org/2000/01/rdf-schema#comment | "The carboxy terminus (CT) of the colonic H(+)-K(+)-ATPase is required for stable assembly with the beta-subunit, translocation to the plasma membrane, and efficient function of the transporter. To identify protein-protein interactions involved in the localization and function of HKalpha(2), we selected 84 amino acids in the CT of the alpha-subunit of mouse colonic H(+)-K(+)-ATPase (CT-HKalpha(2)) as the bait in a yeast two-hybrid screen of a mouse kidney cDNA library. The longest identified clone was CD63. To characterize the interaction of CT-HKalpha(2) with CD63, recombinant CT-HKalpha(2) and CD63 were synthesized in vitro and incubated, and complexes were immunoprecipitated. CT-HKalpha(2) protein (but not CT-HKalpha(1)) coprecipitated with CD63, confirming stable assembly of HKalpha(2) with CD63. In HEK-293 transfected with HKalpha(2) plus beta(1)-Na(+)-K(+)-ATPase, suppression of CD63 by RNA interference increased cell surface expression of HKalpha(2)/NKbeta(1) and (86)Rb(+) uptake. These studies demonstrate that CD63 participates in the regulation of the abundance of the HKalpha(2)-NKbeta(1) complex in the cell membrane."xsd:string |
| http://purl.uniprot.org/citations/15647390 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00463.2004"xsd:string |
| http://purl.uniprot.org/citations/15647390 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/15647390 | http://purl.uniprot.org/core/author | "Codina J."xsd:string |
| http://purl.uniprot.org/citations/15647390 | http://purl.uniprot.org/core/author | "Dubose T.D. Jr."xsd:string |
| http://purl.uniprot.org/citations/15647390 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15647390 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/15647390 | http://purl.uniprot.org/core/pages | "C1279-86"xsd:string |
| http://purl.uniprot.org/citations/15647390 | http://purl.uniprot.org/core/title | "CD63 interacts with the carboxy terminus of the colonic H+-K+-ATPase to decrease plasma membrane localization and 86Rb+ uptake."xsd:string |
| http://purl.uniprot.org/citations/15647390 | http://purl.uniprot.org/core/volume | "288"xsd:string |
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