| http://purl.uniprot.org/citations/15647835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15647835 | http://www.w3.org/2000/01/rdf-schema#comment | "To elucidate the contribution of signal transducer and activator of transcription (STAT) 6 to the pathophysiology of chronic renal injury, STAT6-/-mice were subjected to unilateral ureteral ligation together with wild-type control mice. STAT6-/-kidneys had more apoptotic cells and a greater influx of F4/80-positive cells than wild-type kidneys following ureteral obstruction. There was a much larger alpha-smooth muscle actin-positive area in STAT6-/-kidneys than in wild-type kidneys after ureteral ligation. However, renal fibrosis, as quantified by Masson-Trichrome staining, was not significantly exaggerated in STAT6-/-kidneys compared with wild-type kidneys. The accumulation of collagen I was significantly less in STAT6-/-kidneys than in wild-type kidneys. These observations indicate that the STAT6 signal transduction pathway exerts a protective role on renal cell apoptosis in chronic obstructive uropathy. Our findings also suggest that the STAT6 pathway may have a promotive effect on renal fibrosis by activating collagen synthesis following ureteral obstruction."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Yukawa K."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Maeda M."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Kimura A."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Ichinose M."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Bai T."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Ueyama T."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Goda M."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Tsubota Y."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Liang X.M."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Owada-Makabe K."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/author | "Kishino M."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/pages | "225-230"xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/title | "STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy."xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15647835 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15647835 |
| http://purl.uniprot.org/citations/15647835 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15647835 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K2M3-mappedCitation-15647835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15647835 |
| http://purl.uniprot.org/uniprot/#_P52633-mappedCitation-15647835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15647835 |