| http://purl.uniprot.org/citations/15649154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15649154 | http://www.w3.org/2000/01/rdf-schema#comment | "Defects in apoptotic system may contribute in the pathogenesis and resistance of malignant melanoma cells to chemotherapy. Apoptotic protease-activating factor-1 (Apaf-1) is a cell death effector that acts with cytochrome c and caspase-9 to mediate apoptosis. Recently it was shown that metastatic melanomas often lose Apaf-1 and are concomitantly resistant to apoptosis. It is not known, however, whether Apaf-1 protein is lost during melanoma progression from localized to metastatic tumor. To this end, we evaluated Apaf-1 protein expression by immunohistochemistry in 10 cases of human nevi, 11 melanomas in situ, 26 primary melanomas and 15 metastases. Significant decreases in Apaf-1 expression was observed when comparing nevi and melanomas (chi-square = 33.719; P < 0.0001). Moreover, primary melanomas with greater tumor thickness showed lesser expression of Apaf-1 (chi-square = 16.182; P < 0.003). Intriguingly, we were unable to detect Apaf-1 expression in lesions of metastatic melanomas. These data demonstrated that there is an inverse correlation between Apaf-1 expression and pathologic stage of melanoma. This suggests that the decreased expression of Apaf-1 seen in correlation with melanoma progression renders melanoma more resistant to chemotherapy."xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0749.2004.00205.x"xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/author | "Ueda M."xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/author | "Nishigori C."xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/author | "Ichihashi M."xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/author | "Budiyanto A."xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/author | "Mustika R."xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/name | "Pigment Cell Res"xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/pages | "59-62"xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/title | "Decreased expression of Apaf-1 with progression of melanoma."xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/15649154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15649154 |
| http://purl.uniprot.org/citations/15649154 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15649154 |
| http://purl.uniprot.org/uniprot/#_A7E2A2-mappedCitation-15649154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15649154 |
| http://purl.uniprot.org/uniprot/#_A5YM44-mappedCitation-15649154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15649154 |
| http://purl.uniprot.org/uniprot/#_O14727-mappedCitation-15649154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15649154 |
| http://purl.uniprot.org/uniprot/O14727 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15649154 |
| http://purl.uniprot.org/uniprot/A5YM44 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15649154 |
| http://purl.uniprot.org/uniprot/A7E2A2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15649154 |