| http://purl.uniprot.org/citations/15652357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15652357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15652357 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytoplasmic domain of the transforming growth factor-alpha precursor (proTGFalpha) contains a C-terminal PSD-95/SAP90, Discs Large, and Zona Occludens-1 (PDZ) recognition motif (TVV). By yeast two-hybrid screening of a mouse embryo library, we have found that a third member of a family of PDZ-containing proteins, membrane associated guanylate kinase inverted-3 (MAGI-3), binds to TGFalpha's TVV. MAGI-3 is widely expressed in multiple mouse tissues, including brain. Immunolocalization showed that MAGI-3 and TGFalpha were colocalized in neurons in the cortex and dentate gyrus, as well as in ependymal cells and some astrocytes. In vitro, proTGFalpha bound the PDZ-1 domain of MAGI-3 and MAGI-2, but not MAGI-1. MAGI-3 and the 17-kDa cell surface form of proTGFalpha interact transiently in MDCK cells stably transfected with both MAGI-3 and human proTGFalpha cDNAs. MAGI-3 and wild-type proTGFalpha colocalize at the cell surface. In contrast, MAGI-3 forms a stable complex with membrane-fixed TGFalpha early in the secretory pathway and interacts with immature and cell surface forms of membrane-fixed TGFalpha. Overexpression of MAGI-3 resulted in increased levels of TGFalpha in the basolateral medium of polarized MDCK cells, suggesting that MAGI-3 has a role in efficient trafficking of TGFalpha to the cell surface in polarized epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2004.10.007"xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2004.10.007"xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Dempsey P.J."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Dempsey P.J."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Coffey R.J."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Coffey R.J."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Threadgill D."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Threadgill D."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Yoshiura K."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Yoshiura K."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Franklin J.L."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Franklin J.L."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Pearsall R.S."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Pearsall R.S."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Bogatcheva G."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Bogatcheva G."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Jeyakumar L."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Jeyakumar L."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Meise K.S."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/author | "Meise K.S."xsd:string |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15652357 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |