| http://purl.uniprot.org/citations/15654123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15654123 | http://www.w3.org/2000/01/rdf-schema#comment | "Efforts to elucidate the role of lipoprotein [a] (Lp[a]) in atherogenesis have been hampered by the lack of an animal model with high plasma Lp[a] levels. We produced two lines of transgenic mice expressing apolipoprotein [a] (apo[a]) in the liver and crossed them with mice expressing human apolipoprotein B-100 (apoB-100), generating two lines of Lp[a] mice. One had Lp[a] levels of approximately 700 mg/dl, well above the 30 mg/dl threshold associated with increased risk of atherosclerosis in humans; the other had levels of approximately 35 mg/dl. Most of the LDL in mice with high-level apo[a] expression was covalently bound to apo[a], but most of the LDL in the low-expressing line was free. Using an enzyme-linked sandwich assay with monoclonal antibody EO6, we found high levels of oxidized phospholipids in Lp[a] from high-expressing mice but not in LDL from low-expressing mice or in LDL from human apoB-100 transgenic mice (P <0.00001), even though all mice had similar plasma levels of human apoB-100. The increase in oxidized lipids specific to Lp[a] in high-level apo[a]-expressing mice suggests a mechanism by which increased circulating levels of Lp[a] could contribute to atherogenesis."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m400467-jlr200"xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Taylor J.M."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Schneider M."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Witztum J.L."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Lawn R.M."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Innerarity T.L."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Young S.G."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Ludwig E.H."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Pitas R.E."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Marcovina S.M."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Curtiss L.K."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Miller E.R."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/author | "Tsimikas S."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/pages | "769-778"xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/title | "High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins."xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/15654123 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15654123 |
| http://purl.uniprot.org/citations/15654123 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15654123 |
| http://purl.uniprot.org/uniprot/#_E9Q1Y3-mappedCitation-15654123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15654123 |
| http://purl.uniprot.org/uniprot/#_E9Q414-mappedCitation-15654123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15654123 |
| http://purl.uniprot.org/uniprot/#_E9Q4G4-mappedCitation-15654123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15654123 |