| http://purl.uniprot.org/citations/15655368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15655368 | http://www.w3.org/2000/01/rdf-schema#comment | "The v-Abl tyrosine kinase activates several signaling pathways during transformation of bone marrow cells in mice. Because the SH2-containing inositol 5'-phosphatase (SHIP) and Downstream of tyrosine kinase 1 (Dok1) have been shown to interact with Abl, the effect of SHIP and Dok1 deficiency on v-Abl transformation was investigated. Bone marrow cells from either Dok1- or SHIP-deficient mice are more susceptible to transformation by v-Abl. v-Abl-transformed preB cells from these knockout mice show Abl kinase-dependent hyperproliferation and moderate resistance to apoptosis. Elevated activation of Ras, Raf-1, and Erk, but not of Akt, was observed in either SHIP(-/-) or Dok1(-/-) v-Abl-transformed cells. This activation is sensitive to treatment with STI571. Furthermore, treatment of these cells with either a farnesyltransferase inhibitor or a MEK1/2 inhibitor abrogates the increased proliferation of SHIP(-/-) or Dok1(-/-) cells in a dose-dependent manner. Complementation of SHIP(-/-) or Dok1(-/-) cells abrogates their hyperproliferation and intracellular Erk activation. These data indicate that both SHIP and Dok1 functionally regulate the activation of Ras-Erk pathway by v-Abl and affect the mitogenic activity of v-Abl transformed bone marrow cells."xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/author | "Niki M."xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/author | "Yao P.M."xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/author | "Rothman P.B."xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/author | "Limnander A."xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/author | "Oki S."xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/pages | "310-314"xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/title | "Dok1 and SHIP act as negative regulators of v-Abl-induced pre-B cell transformation, proliferation and Ras/Erk activation."xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/15655368 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15655368 |
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