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http://purl.uniprot.org/citations/15659096http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15659096http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15659096http://www.w3.org/2000/01/rdf-schema#comment"Chloroplast development requires coordinated expression of both nuclear- and chloroplast-encoded genes. To better understand the roles played by nuclear-encoded chloroplast proteins in chloroplast biogenesis, we isolated an Arabidopsis mutant, egy1-1, which has a dual phenotype, reduced chlorophyll accumulation and abnormal hypocotyl gravicurvature. Subsequent map-based cloning and DNA sequencing of the mutant gene revealed a 10-bp deletion in an EGY1 gene, which encodes a 59-kDa metalloprotease that contains eight trans-membrane domains at its C-terminus, and carries out beta-casein degradation in an ATP-independent manner. EGY1 protein accumulation varies between tissue types, being most prominent in leaf and stem tissues, and is responsive to light and ethylene. EGY1-GFP hybrid proteins are localized in the chloroplast. egy1 mutant chloroplasts had reduced granal thylakoids and poorly developed lamellae networks. Furthermore, the accumulation of chlorophyll a/b binding proteins of the light-harvesting complexes I and II (Lhca and Lhcb) are significantly decreased in three separate loss-of-function egy1 mutants. Taken together, these results suggest that EGY1 metalloprotease is required for chloroplast development and, hence, a defective EGY1 gene has pleiotropic effects both on chloroplast development and on ethylene-dependent gravitropism of light-grown hypocotyls."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-313x.2004.02308.x"xsd:string
http://purl.uniprot.org/citations/15659096http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-313x.2004.02308.x"xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/author"Chen G."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/author"Chen G."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/author"Li N."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/author"Li N."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/author"Bi Y.R."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/author"Bi Y.R."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/name"Plant J."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/name"Plant J."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/pages"364-375"xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/pages"364-375"xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/title"EGY1 encodes a membrane-associated and ATP-independent metalloprotease that is required for chloroplast development."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/title"EGY1 encodes a membrane-associated and ATP-independent metalloprotease that is required for chloroplast development."xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/volume"41"xsd:string
http://purl.uniprot.org/citations/15659096http://purl.uniprot.org/core/volume"41"xsd:string
http://purl.uniprot.org/citations/15659096http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15659096
http://purl.uniprot.org/citations/15659096http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15659096
http://purl.uniprot.org/citations/15659096http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15659096
http://purl.uniprot.org/citations/15659096http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15659096