| http://purl.uniprot.org/citations/15661817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15661817 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the effects of persistent elevation of synaptic glycine at Schaffer collateral-CA1 synapses of the hippocampus, we studied the glutamatergic synaptic transmission in acute brain slices from mice with reduced expression of glycine transporter type 1 (GlyT1+/-) as compared to wild type (WT) littermates using whole-cell patch-clamp recordings of CA1 pyramidal cells. We observed faster decay kinetics, reduced ifenprodil sensitivity and increased zinc-induced antagonism in N-methyl-d-aspartate receptor (NMDAR) currents of GlyT1+/-mice. Moreover, the ratio alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR)/NMDAR was decreased in mutants compared to WT. Surprisingly, this change was associated with a reduction in the number of AMPARs expressed at the CA1 synapses in the mutants compared to WT. Overall, these findings highlight the importance of GlyT1 in regulating glutamatergic neurotransmission."xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.org/dc/terms/identifier | "doi:10.1113/jphysiol.2004.080655"xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/author | "Bergeron R."xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/author | "Tiberi M."xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/author | "Coyle J.T."xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/author | "Martina M."xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/author | "Tsai G."xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/author | "B-Turcotte M.E."xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/author | "Halman S."xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/name | "J Physiol"xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/pages | "777-793"xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/title | "Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice."xsd:string |
| http://purl.uniprot.org/citations/15661817 | http://purl.uniprot.org/core/volume | "563"xsd:string |
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