| http://purl.uniprot.org/citations/15662016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15662016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15662016 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1103336"xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1103336"xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/author | "Schwartzberg P.L."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/author | "Schwartzberg P.L."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/author | "Glimcher L.H."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/author | "Glimcher L.H."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/author | "Hwang E.S."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/author | "Hwang E.S."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/author | "Szabo S.J."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/author | "Szabo S.J."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/pages | "430-433"xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/pages | "430-433"xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/title | "T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/title | "T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3."xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/volume | "307"xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://purl.uniprot.org/core/volume | "307"xsd:string |
| http://purl.uniprot.org/citations/15662016 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15662016 |
| http://purl.uniprot.org/citations/15662016 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15662016 |