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| http://purl.uniprot.org/citations/15670770 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling by TNF-family receptor CD40 involves TRAF-family adaptor proteins, leading to activation of protein kinases that induce NFkappaB-family transcription factors. We report here that mitogen activated protein kinase kinase kinase-8 (MAP3K8), Tpl2/COT1, is recruited to the CD40 complex via a mechanism dependent on TRAF-binding sites in CD40. Tpl2/COT1 was shown to participate in CD40 signaling based on the ability of a catalytically inactive mutant to suppress CD40-mediated IkappaB kinase activation and induction of NFkappaB-responsive promoters, without affecting signaling by TNF. Tpl2 (-/-) fibroblasts were also deficient in CD40 but not TNF signaling, further supporting a unique role for Tpl2 in CD40 signaling. Experiments using dominant-negative Tpl2 suggest this kinase functions distal to TRAFs but proximal to the TAK1/TAB1 signaling complex, within the IKK/NFkappaB activation pathway. These results indicate a distinction between TNF Receptor family members CD40 and TNFR1 in their utilization of MAP3Ks, and demonstrate TRAF-dependence of Tpl2 association with the CD40 receptor complex."xsd:string |
| http://purl.uniprot.org/citations/15670770 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.12.155"xsd:string |
| http://purl.uniprot.org/citations/15670770 | http://purl.uniprot.org/core/author | "Reed J.C."xsd:string |
| http://purl.uniprot.org/citations/15670770 | http://purl.uniprot.org/core/author | "Chan H."xsd:string |
| http://purl.uniprot.org/citations/15670770 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15670770 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15670770 | http://purl.uniprot.org/core/pages | "198-205"xsd:string |
| http://purl.uniprot.org/citations/15670770 | http://purl.uniprot.org/core/title | "TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40."xsd:string |
| http://purl.uniprot.org/citations/15670770 | http://purl.uniprot.org/core/volume | "328"xsd:string |
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