| http://purl.uniprot.org/citations/15671033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15671033 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcineurin (CN) is an important regulator of developmental processes and in adults controls the immune response through its regulation of nuclear factor of activated T cells (NFAT). The physical interaction between CN and NFATs is an essential step in the activation of NFAT-dependent genes by calcium signals. Using deletional and substitutional analyses, we have identified a 13-amino acid region within CN that is essential for the interaction with NFAT and with two other CN-binding proteins, AKAP79 and Cabin-1. The interaction of CN with these proteins is selectively disrupted by substitution of specific amino acid residues within this region, indicating that NFAT and other CN-interacting proteins bind differentially to CN. This selectivity suggests that the region identified in CN could be a potential molecular target for immunosuppressive and other therapeutic interventions in diseases involving the CN/NFAT pathway."xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c400401200"xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/author | "Rodriguez A."xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/author | "Redondo J.M."xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/author | "Martinez-Martinez S."xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/author | "Lopez-Maderuelo M.D."xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/author | "Ortega-Perez I."xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/pages | "9980-9984"xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/title | "The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT."xsd:string |
| http://purl.uniprot.org/citations/15671033 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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