| http://purl.uniprot.org/citations/15671036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15671036 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hu family is a group of neuronal RNA-binding proteins required for neuronal differentiation in the developing nervous system. Previously, Hu proteins have been shown to enhance the stabilization and/or translation of target mRNAs, such as p21 (CIP1), by binding to AU-rich elements in untranslated regions (UTRs). In this study, we show that Hu induces p21 expression, cell cycle arrest, and neuronal differentiation in mouse neuroblastoma N1E-115 cells. p21 expression is also up-regulated during Me2SO-induced differentiation in N1E-115 cells and is controlled by post-transcriptional mechanisms through its 3'-UTR. To investigate the molecular mechanisms of Hu functions, we used a proteomics strategy to isolate Hu-interacting proteins and identified heterogeneous nuclear ribonucleoprotein (hnRNP) K. hnRNP K also specifically binds to CU-rich sequences in p21 mRNA 3'-UTR and represses its translation in both nonneuronal and neuronal cells. Further, using RNA interference experiments, we show that the Hu-p21 pathway contributes to the regulation of neurite outgrowth and proliferation in N1E-115 cells, and this pathway is antagonized by hnRNP K. Our results suggest a model in which the mutually antagonistic action of two RNA-binding proteins, Hu and hnRNP K, control the timing of the switch from proliferation to neuronal differentiation through the post-transcriptional regulation of p21 mRNA."xsd:string |
| http://purl.uniprot.org/citations/15671036 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411119200"xsd:string |
| http://purl.uniprot.org/citations/15671036 | http://purl.uniprot.org/core/author | "Yano M."xsd:string |
| http://purl.uniprot.org/citations/15671036 | http://purl.uniprot.org/core/author | "Okano H."xsd:string |
| http://purl.uniprot.org/citations/15671036 | http://purl.uniprot.org/core/author | "Okano H.J."xsd:string |
| http://purl.uniprot.org/citations/15671036 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15671036 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15671036 | http://purl.uniprot.org/core/pages | "12690-12699"xsd:string |
| http://purl.uniprot.org/citations/15671036 | http://purl.uniprot.org/core/title | "Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation."xsd:string |
| http://purl.uniprot.org/citations/15671036 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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