| http://purl.uniprot.org/citations/15673571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15673571 | http://www.w3.org/2000/01/rdf-schema#comment | "Visual information received from the three types of photoreceptor neurons (R1-R6, R7 and R8) in the fly compound eyes converges to the external part of the medulla neuropil (M1-M6 layers) in a layer-specific fashion: R7 and R8 axons terminate at the M6 and M3 layers, respectively, whereas lamina neurons (L1-L5) relay R1-R6 to multiple medulla layers (M1-M5). Here, we show that during development, R7 and R8 neurons establish layer-specific projections in two separate stages: during the first stage, R7 and R8 axons sequentially target to the R7- and R8-temporary layers, respectively; and at the second stage, R7 and R8 growth cones progress synchronously to their destined layers. Using a set of mutations that delete different afferent subsets or alter R7 connectivity, we defined the mechanism of layer selection. We observed that R8, R7 and L1-L5 afferents target to their temporary layers independently, suggesting that afferent-target, but not afferent-afferent, interactions dictate the targeting specificity. N-cadherin is required in the first stage for R7 growth cones to reach and remain in the R7-temporary layer. The Ncad gene contains three pairs of alternatively spliced exons and encodes 12 isoforms. However, expressing a single Ncad isoform in Ncad mutant R7s is sufficient to rescue mistargeting phenotypes. Furthermore, Ncad isoforms mediate promiscuous heterophilic interactions in an in vitro cell-aggregation assay. We propose that Ncad isoforms do not form an adhesion code; rather, they provide permissive adhesion between R7 growth cones and their temporary targets."xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01661"xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/author | "Lee C.H."xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/author | "Robertson H.M."xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/author | "Chung P."xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/author | "Yonekura S."xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/author | "Chiba A."xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/author | "Ting C.Y."xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/author | "Hsu S.N."xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/pages | "953-963"xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/title | "Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents."xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/15673571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15673571 |
| http://purl.uniprot.org/citations/15673571 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15673571 |
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