| http://purl.uniprot.org/citations/15673675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15673675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15673675 | http://www.w3.org/2000/01/rdf-schema#comment | "Ribeye is the only known protein specific to synaptic ribbon, but its function is unclear. We show that the teleost fish, Fugu and zebrafish, have two ribeye genes, ribeye a and ribeye b. Whole-mount in situ hybridization revealed that ribeye a is expressed in tissues containing synaptic ribbons, including the pineal gland, inner ear, and retina. Ribeye b is absent in the pineal gland. In the retina, ribeye a is expressed in both photoreceptors and bipolar cells, whereas ribeye b is detected only in photoreceptors. To study the function of Ribeye a in retina, we depleted it by morpholino antisense oligos. Fish deficient in Ribeye a lack an optokinetic response and have shorter synaptic ribbons in photoreceptors and fewer synaptic ribbons in bipolar cells. Their bipolar cells still target Syntaxin-3 proteins to the inner plexiform layer and have abundant vsx1 mRNA. However, they lack large synaptic terminals and show increased apoptosis. Rod bipolar cells are fewer in number and/or deficient in PKCalpha. Recovery of Ribeye a levels rescues the optokinetic response, increases the number of PKCalpha-positive bipolar cells, and stops apoptosis. We conclude that Ribeye a is important for late steps in bipolar cell development."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.org/dc/terms/identifier | "doi:10.1523/JNEUROSCI.4657-04.2005"xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4657-04.2005"xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/author | "Wan L."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/author | "Wan L."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/author | "Almers W."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/author | "Almers W."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/pages | "941-949"xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/pages | "941-949"xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/title | "Two ribeye genes in teleosts: the role of Ribeye in ribbon formation and bipolar cell development."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/title | "Two ribeye genes in teleosts: the role of Ribeye in ribbon formation and bipolar cell development."xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/15673675 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15673675 |
| http://purl.uniprot.org/citations/15673675 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15673675 |
| http://purl.uniprot.org/citations/15673675 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15673675 |
| http://purl.uniprot.org/citations/15673675 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15673675 |