| http://purl.uniprot.org/citations/15677308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15677308 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of poly(ADP-ribose) (PAR) glycohydrolase (PARG) in the pathophysiology of renal ischemia/reperfusion (I/R) injury is not known. Poly(ADP-ribosyl)ation is rapidly stimulated in cells after DNA damage caused by the generation of reactive oxygen and nitrogen species during I/R. Continuous or excessive activation of poly(ADP-ribose) polymerase-1 produces extended chains of ADP-ribose on nuclear proteins and results in a substantial depletion of intracellular NAD(+) and subsequently, ATP, leading to cellular dysfunction and, ultimately, cell death. The key enzyme involved in polymer turnover is PARG, which possesses mainly exoglycosidase activity but can remove olig(ADP-ribose) fragments via endoglycosidic cleavage. Thus, the aim of this study was to investigate whether the absence of PARG(110) reduced the renal dysfunction, injury, and inflammation caused by I/R of the mouse kidney. Here, the renal dysfunction and injury caused by I/R (bilateral renal artery occlusion [30 min] followed by reperfusion [24 h]) in mice lacking PARG(110), the major nuclear isoform of PARG, was investigated. The following markers of renal dysfunction and injury were measured: Plasma urea, creatinine, aspartate aminotransferase, and histology. The following markers of inflammation were also measured: Myeloperoxidase activity, malondialdehyde levels, and plasma nitrite/nitrate. The degree of renal injury and dysfunction caused by I/R was significantly reduced in PARG(110)-deficient mice when compared with their wild-type littermates, and there were no differences in any of the biochemical parameters measured between sham-operated PARG(110)(-/-) mice and sham-operated wild-type littermates. Thus, it is proposed that endogenous PARG(110) plays a pivotal role in the pathophysiology of I/R injury of the kidney."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2004080677"xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/author | "Wang Z.Q."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/author | "Mazzon E."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/author | "Cuzzocrea S."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/author | "Patel N.S."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/author | "Thiemermann C."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/author | "Cortes U."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/author | "Di Poala R."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/author | "Mota-Filipe H."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/pages | "712-719"xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/title | "Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injury."xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/15677308 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15677308 |
| http://purl.uniprot.org/citations/15677308 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15677308 |
| http://purl.uniprot.org/uniprot/#_E9Q954-mappedCitation-15677308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15677308 |
| http://purl.uniprot.org/uniprot/#_E9Q088-mappedCitation-15677308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15677308 |
| http://purl.uniprot.org/uniprot/#_E9Q7T9-mappedCitation-15677308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15677308 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRU5-mappedCitation-15677308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15677308 |
| http://purl.uniprot.org/uniprot/#_A5YBK2-mappedCitation-15677308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15677308 |
| http://purl.uniprot.org/uniprot/#_O88622-mappedCitation-15677308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15677308 |
| http://purl.uniprot.org/uniprot/#_E9Q3C4-mappedCitation-15677308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15677308 |